During the last years, analysis of conserved gene co-expression networks, predictions about disease-gene and non-coding transcript functions have been conducted and merged together. The research activity was focused on human (specifically cancer and neuro-degenerative disorders) as well as on animal biology in order to deepen the knowledge about the fundamental biological processes: from transcription to post-translational regulatory mechanisms. Data from several high-throughput techniques (microarray, RNA-Seq, ChIP-Seq and other NGS technologies) are analyzed and combined together to offer a more complete and informational picture of physiological and pathological processes of living systems.

• Next Generation Sequencing on poultry

• Ala U., Manco M., Mandili G., Tolosano E., Novelli F., Provero P., Altruda F., Fagoonee S. - Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells - Int J Mol Sci . 2020 Jan 16;21(2):575. doi: 10.3390/ijms21020575.
• Karreth FA., Reschke M., Ruocco A., Ng C., Chapuy B., Léopold V., Sjoberg M., Keane TM., Verma A., Ala U., Tay Y., Wu D., Seitzer N., Velasco-Herrera MD., Bothmer A., Fung J., Langellotto F., Rodig SJ., Elemento O., Shipp MA., Adams DJ., Chiarle R., Pandolfi PP. - The BRAF Pseudogene Functions as a Competitive Endogenous RNA and Induces Lymphoma In Vivo - Cell. 2015 Apr 1. pii: S0092-8674(15)00244-5. PMID: 25843629, DOI: 10.1016/j.cell.2015.02.043
• Lunardi A., Ala U., Epping MT., Salmena L., Clohessy JG., Webster KA., Wang G., Mazzucchelli R., Bianconi M., Stack EC., Lis R., Patnaik A., Cantley LC., Bubley G., Cordon-Cardo C., Gerald WL., Montironi R., Signoretti S., Loda M., Nardella C., Pandolfi PP. - A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer - Nat Genet. 2013 Jun 2;45(7):747-55. PMID: 23727860, DOI: 10.1038/ng.2650
• Ala U., Piro RM., Grassi E., Damasco C., Silengo L., Oti M., Provero P., Di Cunto F. - Prediction of human disease genes by human-mouse conserved coexpression analysis - PloS Comput Biol, 2008 Mar 28 ; 4(3). PMID: 18369433, DOI: 10.1371/journal.pcbi.1000043
• Piro RM., Ala U., Molineris I., Grassi E., Bracco C., Perego GP., Provero P., Di Cunto F. - An atlas of tissue-specific conserved coexpression for functional annotation and disease gene prediction - European Journal of Human Genetics. 2011 Jun 8. PMID: 21654723, DOI: 10.1038/ejhg.2011.96
• Ala U., Karreth FA., Bosia C., Pagnani A., Taulli R., Léopold V., Tay Y., Provero P., Zecchina R., Pandolfi PP. - Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments - Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7154-9. PMID: 23536298, DOI: 10.1073/pnas.1222509110
• Gulluni F., Martini M., De Santis M.C., Campa C.C., Ghigo A., Margaria J.P., Ciraolo E., Franco I., Ugo Ala, Laura Annaratone, Davide Disalvatore, Giovanni Bertalot, Giuseppe Viale, Anna Noatynska, Mara Compagno, Sigismund S., Montemurro F., Thelen M., Fan Fan, Meraldi P., Marchiò C., Pece S., Sapino A., Chiarle R., Di Fiore P.P., Hirsch E. - Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function - Cancer Cell 9 October 2017 http://dx.doi.org/10.1016/j.ccell.2017.09.002
• Annalisa Alfieri, Oksana Sorokina, Annie Adrait, Costanza Angelini, Isabella Russo, Alessandro Morellato, Michela Matteoli, Elisabetta Menna, Elisabetta Boeri Erba, Colin McLean, Douglas J Armstrong, Ugo Ala, Joseph D Buxbaum, Alfredo Brusco, Yohann Coutè, Silvia De Rubeis, Emilia Turco, Paola Defilippi. - Synaptic interactome mining reveals p140Cap as a new hub for PSD proteins involved in psychiatric and neurological disorders - Front. Mol. Neurosci., 30 June 2017 | https://doi.org/10.3389/fnmol.2017.00212 PMID: 28713243