Study and identification of molecules with immuno-modulating properties or of natural origin, with the objective of reducing the use of antibiotics and/or other antimicrobials, with particular regard to the validation of protocols for administering these substances that are compatible with good zootechnical and aquaculture practice and aimed at reducing environmental residues. The use of essential oils in medicated feed in livestock as a valuable strategy to reduce the use of antimicrobials and environmental pollution and to improve animal welfare and food safety.

• Use supercritical fluid extraction with carbon dioxide: mild technology for temperature unstable natural compounds extraction.
• Development a rapid process at low temperature, moderate pressure, nontoxic, non-flammable, chemically stable and inexpensive.
• Essential oils extracted from Ocimum basilicum: antimicrobial efficacy and immuno-stimulating activity evaluation.
• Experimental study on trout (Oncorhynchus mykiss) infected by Lactococcus garvieae, a major aquaculture problem worldwide.
• Validation of protocol for administering. Reduce the use of antimicrobial in fish livestock and environmental pollution.
• Improve animal welfare and food safety.

• Project funded by the Italian Ministry of Health Call for Health Research

• Barbero R., Vercelli C., Dezzutto D., Bergagna S., Gennero M.S., Botto A., Colombo C., Caramelli M., Re G. - In vitro Efficacy of Ocimum Basilicum Essential oil extracted by Supercritical Carbon Dioxide on Lactococcus garviae. Preliminary Results - V International Conference on Antimicrobial Research, Torremolinos - Malaga, Spain, 24-24 May 2018
• Barbero R., Dezzutto D., Bergagna S., Vercelli C., Re G., Botto A., Colombo C., Caramelli M., Gennero M.S. - Natural solution to the antibiotic resistance public health crisis: in vitro investigation on the efficacy of Ocimum basilicum essential oil extracted by supercritical carbon dioxide in rainbow trout (Oncorhynchus mykiss) - 1st International Conference Babies and animals: pediatricians meet vets. 21-22 April 2017.
• Barbero R., Dezzutto D., Bergagna S., Vercelli C., Re G., Botto A., Colombo C., Caramelli M., Gennero M.S. - Antimicrobial activity of essential oils. In vitro efficacy of Ocimum basilicum essential oil extracted by supercritical carbon dioxide in rainbow trout (Oncorhynchus mykiss) affected by Lactococcus garvieae - IV International Conference on Antimicrobial Research, Torremolinos - Malaga, Spain, 29 June - 1 July 2016

• Cell lab – Division of Veterinary Pharmacology and Toxicology

• Dr. Raffaella Barbero - Director DMV - ASL TO 4 (Pubblic Health Service)