Equine asthma

TAG: biopsy, bronchospasm, airway remodeling, inflammation, inflammatory airway disease (IAD), recurrent airway obstruction (RAO)

Equine asthma is a common chronic disease affecting adult horses and causing a wide array of clinical signs. In milder cases, poor performance can be the only preceived sign. However, severely affected horses experience recurrent episodes of respiratory distress at rest. Equine asthma is associated with a reduced quality of life in affected animals and causes large economical losses in the equine industry.
With our research projects, we work towards a better understanding of the physiopathological mechanisms of the disease, especially in terms of airway remodeling and inflammation. Our goal is to implement precision prevention in equine respiratory medicine, for a better prognosis of diseased animals.

PNEUMIPATH - Valutazione del rischio associato all'esposizione ambientale a particelle minerali per lo sviluppo di asma equina/ PNEUMIPATH - Risk of developing equine asthma after exposure to environmental mineral particles
Banca dei tessuti / Equine respiratory tissue bank

Lavoie JP., Bullone M., Rodrigues N., Germim P., Albrecht B., von Salis-Soglio M. - Effect of different doses of inhaled ciclesonide on lung function, clinical signs related to airflow limitation and serum cortisol levels in horses with moderate to severe airway obstruction - -(2019) Equine Vet J, 51(6):779-786.doi: doi.org/10.1111/evj.13093.
Bullone M., Joubert P., Gagné A., Lavoie JP., Hélie P. - Bronchoalveolar lavage fluid neutrophilia is associated with the severity of pulmonary lesions during equine asthma exacerbations - (2018) Equine Vet J, 50(5):609-615. doi: 10.1111/evj.12806.
Bullone M., Pouyet M., Lavoie JP. - Age-associated change in peripheral airway smooth muscle mass of healthy horses - (2017) Vet J, 226:62-64.
Bullone M., Vargas A., Elce Y., Martine GJ., Lavoie JP. - Fluticasone/salmeterol reduces remodelling and neutrophilic inflammation in severe equine asthma - (2017) Sci Rep, 7(1):8843.
Bullone M., Lavoie JP. - Equine asthma diagnosis: bronchoalveolar lavage cytology and beyond -(2017) Equine Vet J, 49(3):263-265.
Bullone M., Hélie P., Joubert P., Lavoie JP. - Development of a semi-quantitative histological score for the assessment of endobronchial biopsies of horses with heaves - (2016) J Vet Intern Med, 30(5):1739-1746.
Bullone M., Murcia RY., Lavoie JP. - Environmental heat and airborne pollen concentration are associated with increased asthma severity in horses - (2016) Equine Vet J, 48(4):479-84.
Herteman N., Bullone M., Lavoie JP. - Endoscopic evaluation of angiogenesis in the large airways of horses with heaves using narrow band imaging - (2016) 'J Vet Intern Med, 30(2):671-4.
Bullone M., de Lagarde M., Vargas A., Lavoie JP. - Serum surfactant protein D and haptoglobin are potential biomarkers for inflammatory airway disease in horses - (2015) J Vet Intern Med, 29(6):1707-11.
Bullone M., Moran K., Lavoie-Lamoureux A., Lavoie JP. - PI3K and MAPKs regulate neutrophil migration toward the airways in heaves - (2012) J Vet Intern Med, 27:164-70.